Molecular Determinants of Decitabine Response in Chronic Myelomonocytic Leukemia
نویسندگان
چکیده
منابع مشابه
Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia.
Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in genes encoding epigenetic modifiers and aberrant DNA methylation. DNA methyltransferase inhibitors (DMTis) are used to treat these disorders, but response is highly variable, with few means to predict which patients will benefit. Here, we examined baseline differences in mutations, DNA methyla...
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Hydroxyurea is the standard therapy of chronic myelomonocytic leukemia (CMML) presenting with advanced myeloproliferative and/or myelodysplastic features. Response to hypomethylating agents has been reported in heterogeneous series of CMML. We conducted a phase 2 trial of decitabine (DAC) in 39 patients with advanced CMML defined according to a previous trial. Median number of DAC cycles was 10...
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*Thorsten Braun,1 *Raphael Itzykson,1,2 Aline Renneville,3 Benoit de Renzis,4 François Dreyfus,5 Kamel Laribi,6 Krimo Bouabdallah,7 Norbert Vey,8 Andrea Toma,9 Christian Recher,10 Bruno Royer,11 Bertrand Joly,12 Anne Vekhoff,13 Ingrid Lafon,14 Laurence Sanhes,15 Guillaume Meurice,2 Cédric Oréar,2 Claude Preudhomme,3 Claude Gardin,1 Lionel Ades,1 Michaela Fontenay,16 Pierre Fenaux,1 Nathalie Dro...
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According to the 2008 World Health Organization classification, chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia are rare diseases. The remarkable progress in our understanding of the molecular genetics of myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms has made it clear that there are some specific genetic abnorm...
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ژورنال
عنوان ژورنال: Blood
سال: 2014
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v124.21.4644.4644